I had a meltdown. I accidentally packed my meds so I was off them for 3 days. It felt like a LIFETIME. It amazes me how well they really work. I have been on antidepressants since I was 17. This specific combo is the first time that I have felt "normal". I take antidepressants and anti-anxiety meds. Without them, I would be a sobbing mess that never leaves the house.